INSIDE THE TANG LAB: DNA DAMAGE & REPAIR
The Double-Edged Sword: DNA Damage & Repair
DNA damage is a natural but dangerous process—while essential for evolution, unchecked damage leads to mutations, cancer, and aging. Our lab quantifies, localizes, and analyzes DNA damage and repair proteins to uncover how cells maintain genetic integrity. By mapping these mechanisms, we aim to understand disease progression and develop targeted therapies for genetic disorders.
Precision in Action: Tools for DNA Repair Research
We leverage mass spectrometry, gene editing, and next-generation sequencing to study DNA damage at the molecular level. By developing cutting-edge techniques, we explore how environmental and metabolic factors contribute to genome instability. These tools allow us to analyze repair protein interactions, uncover novel repair mechanisms, and pave the way for new therapeutic strategies
Rewriting the Genome: A New Era in DNA Research
How does DNA damage lead to cancer? How do repair proteins maintain genome stability? Our lab tackles these questions by integrating chemical biology, biochemistry, and systems biology. Through DNA damage sequencing, proteomics, and interaction studies, we build a comprehensive understanding of DNA repair. Our research not only uncovers fundamental mechanisms but also drives innovation in cancer prevention and treatment.
